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KMID : 0882420040670060662
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Korean Journal of Medicine
2004 Volume.67 No. 6 p.662 ~ p.666
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A case of two consecutive deliveries in a woman with acromegaly
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Choi Hoon
Lee Yeon
Chung Il-Hyung
Koh Jang-Hyun
Kim Mi-Jin
Shin Young-Goo
Chung Choon-Hee
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Abstract
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Acromegaly is a rare pituitary disorder and usually results from GH hypersecretion by a somatotroph adenoma. Disturbed pituitary function might lead to infertility or early pregnancy termination. Pregnancy in acromegaly is very rare. GH is a potent insulin antagonist, and pregnant patients with GH hypersecretion are prone to added glucose intolerance and diabetes. Pregnancy itself may impact the course of a pituitary tumor. In our case, pregnancy was uneventful and normal
full-term infant was delivered at 1993 by vaginal delivery after transsphenoidal surgery and bromocriptine therapy. After delivery, GH and IGF-I level wasn’t normalized. Postoperative pituitary MRI scan showed residual tumor. Therefore she received subsequent postoperative pituitary radiation (total dose : 5000 cGy). Next year, despite elevated GH and IGF-I, she delivered normal full-term infant.
We report a case of two consecutive deliveries in a woman with acromegaly despite elevated GH and IGF-I levels after transsphenoidal surgery and radiation therapy.(Korean J Med 67:662-666, 2004)
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KEYWORD
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Acromegaly, Pregnancy, Growth Hormone
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